Invention Grant
- Patent Title: Photostabilized pharmaceutical compositions
- Patent Title (中): 光稳定药物组合物
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Application No.: US13121852Application Date: 2009-09-30
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Publication No.: US09072791B2Publication Date: 2015-07-07
- Inventor: Koichi Takahashi , Tadashi Morikawa , Tadao Yamazaki , Masaki Shibata
- Applicant: Koichi Takahashi , Tadashi Morikawa , Tadao Yamazaki , Masaki Shibata
- Applicant Address: JP Tokyo
- Assignee: DENKI KAGAKU KOGYO KABUSHIKI KAISHA
- Current Assignee: DENKI KAGAKU KOGYO KABUSHIKI KAISHA
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2008-252254 20080930
- International Application: PCT/JP2009/067018 WO 20090930
- International Announcement: WO2010/038771 WO 20100408
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/715 ; A01N43/90 ; A61K31/519 ; A61K47/48 ; A61K9/00 ; A61K9/08 ; A61K45/06
Abstract:
A crosslinking reaction and a reaction for reducing molecular weight that take place in a hyaluronic acid-methotrexate conjugate upon irradiation with light are suppressed to improve the photostability of the conjugate. Specifically, a substance having a quenching effect and/or a radical scaveng effect is added to a pharmaceutical composition containing the hyaluronic acid-methotrexate conjugate.
Public/Granted literature
- US20110245276A1 PHOTOSTABILIZED PHARMACEUTICAL COMPOSITIONS Public/Granted day:2011-10-06
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