Invention Grant
- Patent Title: Peptides whose uptake by cells is controllable
- Patent Title (中): 细胞摄取的肽是可控的
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Application No.: US13155168Application Date: 2011-06-07
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Publication No.: US09072792B2Publication Date: 2015-07-07
- Inventor: Tao Jiang , Emilia S. Olson , Michael Whitney , Roger Tsien
- Applicant: Tao Jiang , Emilia S. Olson , Michael Whitney , Roger Tsien
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; A61K47/48 ; A61K41/00 ; A61K49/00 ; A61K49/08 ; A61K49/14 ; A61K51/08 ; C07K14/47

Abstract:
A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
Public/Granted literature
- US20120014873A1 PEPTIDES WHOSE UPTAKE BY CELLS IS CONTROLLABLE Public/Granted day:2012-01-19
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