A renal therapy system includes: a filter; an arterial blood flowpath in fluid communication with the filter; a venous blood flowpath in fluid communication with the filter; extracorporeal circuit including the filter, the arterial blood flowpath and the venous blood flowpath; a renal therapy fluid flowpath in fluid communication with the extracorporeal circuit; a plurality of renal therapy fluid valves; and first and second renal therapy fluid pumps, wherein the system is configured to operate the plurality of renal therapy fluid valves so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the extracorporeal circuit for a number of first pump actuations and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath for a number of second pump actuations.