A cleaning case for a portable electronic device such as a mobile phone or tablet computer. The case is adapted to be secured to or receive a lower side or face of the electronic device, and includes a housing with a wipe storage compartment for a reusable screen wipe. The wipe can be pulled from the storage compartment in a flat sheet configuration through a slot in the housing, up and around the housing and device mounted thereon, in order to clean the screen of the device. The housing further includes a retraction means for retracting the wipe back into the storage compartment after use. The case may also be formed integrally with the electronic device.