Invention Grant
- Patent Title: Methods and intermediates for preparing macrolactams
- Patent Title (中): 制备大环内酯的方法和中间体
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Application No.: US14239391Application Date: 2012-08-16
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Publication No.: US09073825B2Publication Date: 2015-07-07
- Inventor: Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
- Applicant: Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
- Applicant Address: GB Hertfordshire US NJ Rahway
- Assignee: Merck Sharp & Dohme Limited,Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Limited,Merck Sharp & Dohme Corp.
- Current Assignee Address: GB Hertfordshire US NJ Rahway
- Agent Julie M. Lake; Laura M. Ginkel
- International Application: PCT/US2012/051182 WO 20120816
- International Announcement: WO2013/028471 WO 20130228
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A01N43/42 ; C07C35/04 ; C07K5/083 ; C07D403/12 ; C07D498/16 ; C07K5/12 ; C07C67/14 ; C07C69/013 ; C07C69/12 ; C07C269/04 ; C07C271/34 ; A61K38/00
Abstract:
A first aspect of the present invention describes a compound selected from group consisting of: wherein R is either H, C(O)RA, or C(O)NHCH(X)COOH; provided that X is a C2-C6 alkyl, or a C3-C8 cycloalkyl and RA is a C1-6 alkyl or aryl; These compounds are used to make Compound A
Public/Granted literature
- US20140243519A1 METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS Public/Granted day:2014-08-28
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