Invention Grant
US09073835B2 N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway
有权
刺猬蛋白信号通路的N-酰基硫脲和N-酰基脲抑制剂
- Patent Title: N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway
- Patent Title (中): 刺猬蛋白信号通路的N-酰基硫脲和N-酰基脲抑制剂
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Application No.: US12988975Application Date: 2009-04-16
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Publication No.: US09073835B2Publication Date: 2015-07-07
- Inventor: Martial Ruat , Hélène Faure , Elisabeth Traiffort , Angèle Schoenfelder , André Mann , Maurizio Taddei , Antonio Solinas , Fabrizio Manetti
- Applicant: Martial Ruat , Hélène Faure , Elisabeth Traiffort , Angèle Schoenfelder , André Mann , Maurizio Taddei , Antonio Solinas , Fabrizio Manetti
- Applicant Address: FR Paris FR Strasbourg Cedex
- Assignee: Centre National De La Recherche Scientifique,Universite De Strasbourg
- Current Assignee: Centre National De La Recherche Scientifique,Universite De Strasbourg
- Current Assignee Address: FR Paris FR Strasbourg Cedex
- Agency: Alston & Bird LLP
- Priority: FR0802302 20080424
- International Application: PCT/FR2009/000442 WO 20090416
- International Announcement: WO2009/130422 WO 20091029
- Main IPC: C07C275/54
- IPC: C07C275/54 ; C07C335/26 ; C07D213/81 ; C07D209/08 ; C07D209/14 ; C07D235/14 ; C07D307/68 ; C07D317/68 ; C07D319/18 ; C07D333/38 ; C07D471/04 ; C07D513/04 ; C07D235/18 ; C07C335/08
Abstract:
The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivatives as such, to their use as a medicinal product, and to pharmaceutical compositions containing them.
Public/Granted literature
- US20110275663A1 N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway Public/Granted day:2011-11-10
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