Invention Grant
US09073863B2 Cyanoquinoline compounds having activity in correcting mutant-CFTR processing and increasing ion transport and uses thereof
有权
具有校正突变体CFTR处理和增加离子迁移活性的氰基喹啉化合物及其用途
- Patent Title: Cyanoquinoline compounds having activity in correcting mutant-CFTR processing and increasing ion transport and uses thereof
- Patent Title (中): 具有校正突变体CFTR处理和增加离子迁移活性的氰基喹啉化合物及其用途
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Application No.: US14122193Application Date: 2012-05-25
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Publication No.: US09073863B2Publication Date: 2015-07-07
- Inventor: Alan S. Verkman , Puay-Wah Phuan , Mark J. Kurth , John Knapp
- Applicant: Alan S. Verkman , Puay-Wah Phuan , Mark J. Kurth , John Knapp
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Rudy J. Ng; Carol L. Francis
- Priority: CA2754237 20110929
- International Application: PCT/US2012/039706 WO 20120525
- International Announcement: WO2012/166654 WO 20121206
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D215/54 ; C07D409/12 ; C07D409/14 ; C07D401/12
Abstract:
The present disclosure provides pharmaceutical compositions, pharmaceutical preparations and methods for increasing activity of a mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR). The pharmaceutical compositions, pharmaceutical preparations and methods are useful for the study and treatment of disorders associated with mutant-CFTR, such as cystic fibrosis. The pharmaceutical compositions and pharmaceutical preparations may include one or more cyanoquinoline-containing compounds of the embodiments, or an analog or derivative thereof.
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