Invention Grant
US09073869B2 Method of using substituted 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
有权
使用取代的2-氮杂 - 双环[2.2.2]辛烷-3-羧酸（苄基 - 氰基 - 甲基） - 酰胺组织蛋白酶C抑制剂的方法
![Method of using substituted 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C](/docs/US/2015-07-07/US09073869B2/abs.jpg.600x600.jpg)
- Patent Title: Method of using substituted 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
- Patent Title (中): 使用取代的2-氮杂 - 双环[2.2.2]辛烷-3-羧酸（苄基 - 氰基 - 甲基） - 酰胺组织蛋白酶C抑制剂的方法
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Application No.: US14483217Application Date: 2014-09-11
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Publication No.: US09073869B2Publication Date: 2015-07-07
- Inventor: Ralf Anderskewitz , Matthias Grauert , Marc Grundl , Thorsten Oost , Alexander Pautsch , Stefan Peters
- Applicant: Ralf Anderskewitz , Matthias Grauert , Marc Grundl , Thorsten Oost , Alexander Pautsch , Stefan Peters
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Atabak R. Royaee
- Priority: EP13159242 20130314; EP13170006 20130531
- Main IPC: A61K31/439
- IPC: A61K31/439 ; A61K31/4725 ; A61K45/06 ; C07D221/22 ; C07D401/12 ; C07D417/12 ; C07D453/06
![Method of using substituted 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C](/abs-image/US/2015/07/07/US09073869B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
Public/Granted literature
Information query
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