Invention Grant
US09073870B2 Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
有权
苯并呋喃和相关支架的脂环族羧酸衍生物，含有这些化合物的药物及其应用
- Patent Title: Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
- Patent Title (中): 苯并呋喃和相关支架的脂环族羧酸衍生物，含有这些化合物的药物及其应用
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Application No.: US14191951Application Date: 2014-02-27
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Publication No.: US09073870B2Publication Date: 2015-07-07
- Inventor: Stefan Peters , Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach , Joerg Kley
- Applicant: Stefan Peters , Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach , Joerg Kley
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; David L. Kershner
- Priority: EP08156122 20080513
- Main IPC: A61K31/439
- IPC: A61K31/439 ; C07D221/22 ; C07D221/26 ; C07D471/18 ; C07D491/18 ; C07D401/06 ; C07D401/08 ; C07D401/12 ; C07D405/06 ; C07D405/12 ; C07D491/08
Abstract:
The present invention relates to compounds defined by formula I wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
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