Invention Grant
- Patent Title: Oxazole derivatives useful as modulators of FAAH
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Application No.: US13635286Application Date: 2011-04-18
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Publication No.: US09073879B2Publication Date: 2015-07-07
- Inventor: Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
- Applicant: Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
- Applicant Address: US NJ Rahway
- Assignee: MERCK SHARP & DOHME CORP.
- Current Assignee: MERCK SHARP & DOHME CORP.
- Current Assignee Address: US NJ Rahway
- Agent Matthew A. Leff; John C. Todaro
- International Application: PCT/US2011/032842 WO 20110418
- International Announcement: WO2011/133447 WO 20111027
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D413/14 ; C07D263/46 ; A61K31/4545 ; A61K31/444 ; A61K31/422 ; C07D473/32 ; A61K31/52 ; C07D413/04 ; A61P19/02 ; A61P29/00 ; A61P25/00 ; A61P25/06 ; A61P25/20 ; A61P25/28 ; A61P25/16 ; A61K31/4439
Abstract:
The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.
Public/Granted literature
- US20130012526A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH Public/Granted day:2013-01-10
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