Invention Grant
- Patent Title: Inhibitors of the renal outer medullary potassium channel
- Patent Title (中): 肾外髓质钾通道抑制剂
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Application No.: US13881008Application Date: 2011-10-21
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Publication No.: US09073882B2Publication Date: 2015-07-07
- Inventor: Haifeng Tang , Alexander Pasternak , Lihu Yang , Shawn P. Walsh , Barbara Pio , Aurash Shahripour , Nardos Teumelsan
- Applicant: Haifeng Tang , Alexander Pasternak , Lihu Yang , Shawn P. Walsh , Barbara Pio , Aurash Shahripour , Nardos Teumelsan
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; Catherine D. Fitch
- International Application: PCT/US2011/057346 WO 20111021
- International Announcement: WO2012/058116 WO 20120503
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D295/15 ; C07D295/135 ; C07D295/155 ; C07D213/76 ; C07D405/14 ; C07D407/12 ; C07D213/61 ; C07D241/04 ; C07D271/04 ; C07D295/073 ; C07D307/88 ; C07D309/30 ; C07D405/12 ; C07D413/12 ; A61K31/551 ; A61K31/4745 ; C07D271/12 ; C07D471/08 ; C07D487/08
Abstract:
This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
Public/Granted literature
- US20130225561A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Public/Granted day:2013-08-29
Information query
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