Invention Grant
- Patent Title: Rock inhibitors
- Patent Title (中): 岩石抑制剂
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Application No.: US14113941Application Date: 2012-04-27
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Publication No.: US09073905B2Publication Date: 2015-07-07
- Inventor: Dirk Leysen , Olivier Defert , Sandro Boland , Jo Alen , Arnaud Pierre Jean Bourin
- Applicant: Dirk Leysen , Olivier Defert , Sandro Boland , Jo Alen , Arnaud Pierre Jean Bourin
- Applicant Address: BE Diepenbeek
- Assignee: Amakem NV
- Current Assignee: Amakem NV
- Current Assignee Address: BE Diepenbeek
- Agency: Dinsmore & Shohl LLP
- Priority: GB1107223.8 20110429
- International Application: PCT/EP2012/057785 WO 20120427
- International Announcement: WO2012/146724 WO 20121101
- Main IPC: C07D409/14
- IPC: C07D409/14 ; C07D401/12 ; C07D401/14 ; C07D405/14 ; C07D451/04 ; A61K31/4725 ; A61K31/439 ; A61K31/4468

Abstract:
The present invention relates to new kinase inhibitors of Formula (I), wherein X is oxygen, —NH—, or a direct bond; Y is —NH— or a direct bond; n is an integer from 0 to 4; m is an integer from 0 to 4; Cy represents a bivalent radical consisting of a satured (poly)cycle, including fused, bi-, spiro or bridged carbocycles and heterocycles; in particular selected from the group consisting of: Formula (II), Ar is selected from the group comprising: Formula (III), R2 is hydrogen or methyl; R8 is hydrogen, methyl, halogen, or alkynyl; R1 is an aryl or heteroaryl more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.
Public/Granted literature
- US20140057942A1 NOVEL ROCK INHIBITORS Public/Granted day:2014-02-27
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