Invention Grant
- Patent Title: Aldosterone synthase inhibitors
- Patent Title (中): 醛固酮合酶抑制剂
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Application No.: US14112945Application Date: 2012-04-20
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Publication No.: US09073929B2Publication Date: 2015-07-07
- Inventor: Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
- Applicant: Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
- Applicant Address: DE Saarbrucken US NJ Rahway
- Assignee: ElexoPharm GmbH,Merck Sharp & Dohme Corp.
- Current Assignee: ElexoPharm GmbH,Merck Sharp & Dohme Corp.
- Current Assignee Address: DE Saarbrucken US NJ Rahway
- Agent Kenrick L. Vidale; Catherine D. Fitch
- International Application: PCT/US2012/034417 WO 20120420
- International Announcement: WO2012/148808 WO 20121101
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D487/04 ; C07D519/00 ; A61K31/41 ; A61K45/06

Abstract:
This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
Public/Granted literature
- US20140045819A1 ALDOSTERONE SYNTHASE INHIBITORS Public/Granted day:2014-02-13
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