Invention Grant
- Patent Title: Method for the N-demethylation of N-methyl heterocycles
- Patent Title (中): N-甲基杂环N-去甲基化方法
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Application No.: US13496562Application Date: 2010-09-16
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Publication No.: US09073934B2Publication Date: 2015-07-07
- Inventor: Peter John Scammells , Gaik Orbell
- Applicant: Peter John Scammells , Gaik Orbell
- Applicant Address: AU Clayton
- Assignee: MONASH UNIVERSITY
- Current Assignee: MONASH UNIVERSITY
- Current Assignee Address: AU Clayton
- Agency: McCarter & English, LLP
- Agent Elizabeth A. Hanley, Esq.; Yu Lu
- Priority: AU2009904493 20090916
- International Application: PCT/AU2010/001204 WO 20100916
- International Announcement: WO2011/032214 WO 20110324
- Main IPC: C07D489/08
- IPC: C07D489/08 ; C07D451/02 ; C07B37/06 ; C07D451/00 ; C07D451/06 ; C07D451/10 ; C07D489/00 ; C07D489/02

Abstract:
The present invention provides methods of N-demethylating, N-methylated heterocycles and N-methyl, N-oxide heterocycles using a transition metal with an oxidation state of zero, ferrocene or substituted derivatives thereof, or Cr3+. N-demethylated heterocycles prepared by the methods of the present invention are also provided.
Public/Granted literature
- US20120226043A1 METHOD FOR THE N-DEMETHYLATION OF N-METHYL HETEROCYCLES Public/Granted day:2012-09-06
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