Invention Grant
- Patent Title: Compounds and methods for treating tuberculosis infection
- Patent Title (中): 治疗结核病感染的化合物和方法
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Application No.: US13806228Application Date: 2011-06-28
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Publication No.: US09073941B2Publication Date: 2015-07-07
- Inventor: Chi-Huey Wong , Ying-Ta Wu
- Applicant: Chi-Huey Wong , Ying-Ta Wu
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2011/042217 WO 20110628
- International Announcement: WO2012/006104 WO 20120112
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07D498/04 ; C07C49/753 ; C07C49/755 ; C07D401/12 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D487/04
Abstract:
The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and/or the growth of tubercle bacillus, and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and/or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and/or PDH activity key to a pathogen's survival.
Public/Granted literature
- US20130345223A9 COMPOUNDS AND METHODS FOR TREATING TUBERCULOSIS INFECTION Public/Granted day:2013-12-26
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