Invention Grant
US09073958B2 Aminoglycosides and uses thereof in the treatment of genetic disorders
有权
氨基糖苷类及其在治疗遗传疾病中的用途
- Patent Title: Aminoglycosides and uses thereof in the treatment of genetic disorders
- Patent Title (中): 氨基糖苷类及其在治疗遗传疾病中的用途
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Application No.: US12285299Application Date: 2008-10-01
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Publication No.: US09073958B2Publication Date: 2015-07-07
- Inventor: Timor Baasov , Tamar Ben-Yosef , Igor Nudelman , Annie Rebibo-Sabbah , Dalia Shallom-Shezifi , Mariana Hainrichson
- Applicant: Timor Baasov , Tamar Ben-Yosef , Igor Nudelman , Annie Rebibo-Sabbah , Dalia Shallom-Shezifi , Mariana Hainrichson
- Applicant Address: IL Haifa
- Assignee: Technion Research & Development Foundation Limited
- Current Assignee: Technion Research & Development Foundation Limited
- Current Assignee Address: IL Haifa
- Main IPC: A61K31/7036
- IPC: A61K31/7036 ; C07H5/06
Abstract:
A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
Public/Granted literature
- US20090093418A1 Novel aminoglycosides and uses thereof in the treatment of genetic disorders Public/Granted day:2009-04-09
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