Invention Grant
US09073964B2 Inhibitors of atypical protein kinase C and their use in treating hedgehog pathway-dependent cancers
有权
非典型蛋白激酶C的抑制剂及其在治疗刺猬蛋白通路依赖性癌症中的应用
- Patent Title: Inhibitors of atypical protein kinase C and their use in treating hedgehog pathway-dependent cancers
- Patent Title (中): 非典型蛋白激酶C的抑制剂及其在治疗刺猬蛋白通路依赖性癌症中的应用
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Application No.: US13422936Application Date: 2012-03-16
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Publication No.: US09073964B2Publication Date: 2015-07-07
- Inventor: Scott X. Atwood , Anthony Oro
- Applicant: Scott X. Atwood , Anthony Oro
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Edward J. Baba; Shweta Chandra
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K7/06 ; C07K7/08 ; C07D403/12 ; A61K31/713 ; C07D491/107 ; C07D211/40 ; C12N15/113
Abstract:
Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.
Public/Granted literature
- US20120283194A1 Inhibitors of Atypical Protein Kinase C and Their Use in Treating Hedgehog Pathway-Dependent Cancers Public/Granted day:2012-11-08
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