Invention Grant
US09073978B2 Method for producing glycopeptide having sialyl sugar chain, sialyl sugar chain-added amino acid derivative to be used in same, and glycopeptide
有权
制备具有唾液酸糖链的糖肽的方法，用于其中的唾液酸糖链加成氨基酸衍生物和糖肽
- Patent Title: Method for producing glycopeptide having sialyl sugar chain, sialyl sugar chain-added amino acid derivative to be used in same, and glycopeptide
- Patent Title (中): 制备具有唾液酸糖链的糖肽的方法，用于其中的唾液酸糖链加成氨基酸衍生物和糖肽
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Application No.: US14004122Application Date: 2012-03-05
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Publication No.: US09073978B2Publication Date: 2015-07-07
- Inventor: Yasuhiro Kajihara , Masumi Murakami , Kazuyuki Ishii
- Applicant: Yasuhiro Kajihara , Masumi Murakami , Kazuyuki Ishii
- Applicant Address: JP Shimogyo-ku, Kyoto-shi, Kyoto
- Assignee: Glytech, Inc.
- Current Assignee: Glytech, Inc.
- Current Assignee Address: JP Shimogyo-ku, Kyoto-shi, Kyoto
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- Priority: JP2011-053644 20110310; JP2012-021367 20120202
- International Application: PCT/JP2012/055543 WO 20120305
- International Announcement: WO2012/121206 WO 20120913
- Main IPC: C07H1/00
- IPC: C07H1/00 ; C07K1/06 ; C07K14/00 ; C07K1/00
Abstract:
[Technical Problem]To provide a method for manufacturing that enables to obtain a targeted glycopeptide harboring a sialyl sugar chain in high yield without decomposing sialic acid at a non-reducing terminal of sugar chain when the glycopeptide is synthesized by a Boc solid phase synthesis method.[Solution to Problem]The present invention is characterized in that the Boc-sialylglycosylated amino acid derivative used in Boc solid phase synthesis method is one where the carboxyl group of the sialic acid at the sugar chain non-reducing terminal is protected with a phenacyl group.
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