Invention Grant
- Patent Title: Tumor selective E1a and E1b mutants
- Patent Title (中): 肿瘤选择性E1a和E1b突变体
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Application No.: US13254825Application Date: 2010-03-02
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Publication No.: US09073980B2Publication Date: 2015-07-07
- Inventor: Tony Reid , Farah Hedjran , Shantanu Kumar
- Applicant: Tony Reid , Farah Hedjran , Shantanu Kumar
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- International Application: PCT/US2010/025926 WO 20100302
- International Announcement: WO2010/101921 WO 20100910
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C12N7/00 ; C12N15/86 ; A61K48/00
Abstract:
Modified E1a regulatory sequences are provided, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. Also provided are modified E1a sequences that selectively express particular isoforms. Also provided is an E1b-19K clone insertion site. These modified sequences can be used individually, or in combination with one another, to provide tumor-selective expression of proteins.
Public/Granted literature
- US20110318311A1 TUMOR-SELECTIVE E1A AND E1B MUTANTS Public/Granted day:2011-12-29
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