Invention Grant
- Patent Title: Dengue virus neutralizing antibodies and use thereof
- Patent Title (中): 登革热病毒中和抗体及其用途
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Application No.: US13124076Application Date: 2009-10-13
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Publication No.: US09073981B2Publication Date: 2015-07-07
- Inventor: Antonio Lanzavecchia
- Applicant: Antonio Lanzavecchia
- Applicant Address: CH Bellinzona
- Assignee: Institute for Research in Biomedicine
- Current Assignee: Institute for Research in Biomedicine
- Current Assignee Address: CH Bellinzona
- Agent Dennis A. Bennett
- International Application: PCT/IB2009/007372 WO 20091013
- International Announcement: WO2010/043977 WO 20100422
- Main IPC: C07K16/10
- IPC: C07K16/10
Abstract:
The invention relates to antibodies and antigen binding fragments thereof and to cocktails of antibodies and antigen binding fragments that neutralize dengue virus infection without contributing to antibody-dependent enhancement of dengue virus infection. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antigen binding fragments. In addition, the invention relates to the use of the antibodies, antigen binding fragments, and epitopes in screening methods as well as in the diagnosis and therapy of dengue virus infection.
Public/Granted literature
- US20120020957A1 DENGUE VIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF Public/Granted day:2012-01-26
Information query
