Invention Grant
- Patent Title: Fed batch method of making anti-TNF-alpha antibodies
- Patent Title (中): 联合分批法制备抗TNF-α抗体
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Application No.: US14563993Application Date: 2014-12-08
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Publication No.: US09073988B2Publication Date: 2015-07-07
- Inventor: Itzcoatl A. Pla , Joseph G. Matuck , John C. Fann , Christof Schulz , Nichole A. Roy , David F. Bruton , James McIntire , Yu-hsiang D. Chang , Thomas Seewoester
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: Foley Hoag LLP
- Main IPC: C12P1/00
- IPC: C12P1/00 ; C12P21/04 ; C12N5/07 ; C12N5/16 ; C12N5/10 ; C12N5/00 ; C12N5/02 ; C07K16/24 ; C07K16/00 ; C07K16/28 ; C12N5/073
Abstract:
The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.
Public/Granted literature
- US20150087024A1 Cell Culture Improvements Public/Granted day:2015-03-26
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