Invention Grant
- Patent Title: Human anti TSHR antibodies
- Patent Title (中): 人抗TSHR抗体
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Application No.: US13142217Application Date: 2009-12-23
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Publication No.: US09073992B2Publication Date: 2015-07-07
- Inventor: Bernard Rees-Smith , Jane Sanders , Jadwiga Furmaniak
- Applicant: Bernard Rees-Smith , Jane Sanders , Jadwiga Furmaniak
- Applicant Address: GB Cardiff, South Glamorgan
- Assignee: RSR Ltd.
- Current Assignee: RSR Ltd.
- Current Assignee Address: GB Cardiff, South Glamorgan
- Agency: Fish & Richardson P.C.
- Priority: GB0823562.4 20081224; GB0908945.9 20090522
- International Application: PCT/GB2009/002946 WO 20091223
- International Announcement: WO2010/073012 WO 20100701
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
According to one aspect there is provided an isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity, wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.
Public/Granted literature
- US20110300138A1 HUMAN ANTI TSHR ANTIBODIES Public/Granted day:2011-12-08
Information query
