Invention Grant
- Patent Title: Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
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Application No.: US12396286Application Date: 2009-03-02
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Publication No.: US09073998B2Publication Date: 2015-07-07
- Inventor: Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
- Applicant: Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
- Applicant Address: US CA Fremont
- Assignee: Amgen Fremont Inc.
- Current Assignee: Amgen Fremont Inc.
- Current Assignee Address: US CA Fremont
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C07K16/28 ; C07K14/71 ; A61K39/395 ; B82Y5/00 ; A61K39/00
Abstract:
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
Public/Granted literature
- US20090175887A1 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF Public/Granted day:2009-07-09
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