Invention Grant
- Patent Title: Molecular control of brown fat differentiation and energy expenditure
- Patent Title (中): 棕色脂肪分化和能量消耗的分子控制
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Application No.: US12446110Application Date: 2007-10-17
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Publication No.: US09074012B2Publication Date: 2015-07-07
- Inventor: Patrick Seale , Bruce M. Spiegelman
- Applicant: Patrick Seale , Bruce M. Spiegelman
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Foley Hoag LLP
- International Application: PCT/US2007/022162 WO 20071017
- International Announcement: WO2008/063330 WO 20080529
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/63 ; C12N15/85 ; C07K14/00 ; C07H21/04 ; C07K14/47 ; C12N5/077
Abstract:
The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of Prdm 16 activity or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of Prdm 16 expression or activity. Further provided are methods for identifying compounds that are capable of modulating Prdm 16 expression or activity.
Public/Granted literature
- US20110059051A1 Molecular Control of Brown Fat Differentiation and Engergy Expenditure Public/Granted day:2011-03-10
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