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US09074187B2 Nanostructural materials that increase mineralization in bone cells and affect gene expression through miRNA regulation and applications of same 有权
纳米结构材料通过miRNA调节和应用增加骨细胞矿化并影响基因表达

Nanostructural materials that increase mineralization in bone cells and affect gene expression through miRNA regulation and applications of same
Abstract:
A method of inducing mineralization in a bone cell is described. The method comprises contacting a bone cell with a composition comprising nanoparticles. The nanoparticles can be single-walled carbon nanotubes, hydroxyapatite nanoparticles, TiO2 nanoparticles or silver nanoparticles. The bone cell can be an osteoblast cell. A method for increasing bone mass, bone healing or bone formation is also described which comprises administering to a subject in need thereof an effective amount of a composition comprising nanoparticles. The subject can suffer from a bone disease such as osteoporosis. The subject can suffer from a bone fracture and the method can comprise contacting bone cells near the bone fracture site with the composition. The composition can further comprise a pharmaceutically acceptable carrier.
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