Invention Grant
- Patent Title: Nanostructural materials that increase mineralization in bone cells and affect gene expression through miRNA regulation and applications of same
- Patent Title (中): 纳米结构材料通过miRNA调节和应用增加骨细胞矿化并影响基因表达
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Application No.: US13426154Application Date: 2012-03-21
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Publication No.: US09074187B2Publication Date: 2015-07-07
- Inventor: Alexandru S. Biris , Daniel Casciano , Meena Waleed Mahmood
- Applicant: Alexandru S. Biris , Daniel Casciano , Meena Waleed Mahmood
- Applicant Address: US AR Little Rock
- Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
- Current Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
- Current Assignee Address: US AR Little Rock
- Agency: Morris, Manning & Martin, LLP
- Agent Tim Tingkang Xia, Esq.
- Main IPC: A61K33/00
- IPC: A61K33/00 ; A61K33/42 ; A61K9/00 ; A61K9/14 ; A61K39/395 ; A61P19/00 ; A61P19/10 ; C12N5/02 ; A61K33/24 ; B82Y5/00 ; C12N5/077 ; A61K33/26 ; A61L27/50

Abstract:
A method of inducing mineralization in a bone cell is described. The method comprises contacting a bone cell with a composition comprising nanoparticles. The nanoparticles can be single-walled carbon nanotubes, hydroxyapatite nanoparticles, TiO2 nanoparticles or silver nanoparticles. The bone cell can be an osteoblast cell. A method for increasing bone mass, bone healing or bone formation is also described which comprises administering to a subject in need thereof an effective amount of a composition comprising nanoparticles. The subject can suffer from a bone disease such as osteoporosis. The subject can suffer from a bone fracture and the method can comprise contacting bone cells near the bone fracture site with the composition. The composition can further comprise a pharmaceutically acceptable carrier.
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