Invention Grant
- Patent Title: Inhibition of AXL signaling in anti-metastatic therapy
- Patent Title (中): 抗转移治疗中AXL信号传导的抑制作用
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Application No.: US13595936Application Date: 2012-08-27
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Publication No.: US09074192B2Publication Date: 2015-07-07
- Inventor: Amato J. Giaccia , Erinn Bruno Rankin , Jennifer R. Cochran , Douglas Jones , Mihalis Kariolis , Katherine Fuh , Yu Miao
- Applicant: Amato J. Giaccia , Erinn Bruno Rankin , Jennifer R. Cochran , Douglas Jones , Mihalis Kariolis , Katherine Fuh , Yu Miao
- Applicant Address: US CA Palo Alto
- Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C12N9/12 ; A61K38/45 ; C07K16/22 ; A61K45/06 ; C07K14/71
Abstract:
Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6.
Public/Granted literature
- US20130108644A1 Inhibition of AXL Signaling in Anti-Metastatic Therapy Public/Granted day:2013-05-02
Information query
