Invention Grant
- Patent Title: Modified siRNA molecules and uses thereof
- Patent Title (中): 修饰的siRNA分子及其用途
-
Application No.: US13952529Application Date: 2013-07-26
-
Publication No.: US09074208B2Publication Date: 2015-07-07
- Inventor: Ian MacLachlan , Adam Judge
- Applicant: Protiva Biotherapeutics, Inc.
- Applicant Address: CA Burnaby, BC
- Assignee: PROTIVA BIOTHERAPEUTICS, INC.
- Current Assignee: PROTIVA BIOTHERAPEUTICS, INC.
- Current Assignee Address: CA Burnaby, BC
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113 ; A61K9/127 ; A61K31/713 ; A61K48/00 ; C12N15/11
Abstract:
The present invention provides chemically modified siRNA molecules and methods of using such siRNA molecules to silence target gene expression. Advantageously, the modified siRNA of the present invention is less immunostimulatory than its corresponding unmodified siRNA sequence and retains RNAi activity against the target sequence. The present invention also provides nucleic acid-lipid particles comprising a modified siRNA, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. The present invention further provides methods of silencing gene expression by administering a modified siRNA to a mammalian subject. Methods for identifying and/or modifying an siRNA having immunostimulatory properties are also provided.
Public/Granted literature
- US20140179756A1 MODIFIED SIRNA MOLECULES AND USES THEREOF Public/Granted day:2014-06-26
Information query
