Invention Grant
- Patent Title: TRPM-2 antisense therapy
- Patent Title (中): TRPM-2反义治疗
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Application No.: US14027693Application Date: 2013-09-16
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Publication No.: US09074209B2Publication Date: 2015-07-07
- Inventor: Martin Gleave , Paul S. Rennie , Hideaki Miyake , Colleen Nelson
- Applicant: Martin Gleave , Paul S. Rennie , Hideaki Miyake , Colleen Nelson
- Applicant Address: CA Vancouver
- Assignee: The University of British Columbia
- Current Assignee: The University of British Columbia
- Current Assignee Address: CA Vancouver
- Agency: Larson & Anderson, LLC
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/00 ; A61K31/337 ; A61K31/66 ; A61K31/704 ; A61K41/00 ; A61K45/06 ; C07H21/00 ; C07K14/775 ; A61K48/00
Abstract:
A method for treating an individual suffering from a cancer comprising administering to the individual i) a chemotherapeutic agent, and ii) one antisense oligonucleotide having nucleotides in the sequence set forth in Seq. ID No. 4 and which antisense oligonucleotide has a phosphorothioate modification that increases the stability thereof in vivo, wherein the cancer expresses testosterone-repressed prostate message-2 (TRPM-2), thereby treating said individual.
Public/Granted literature
- US20140100261A1 TRPM-2 ANTISENSE THERAPY Public/Granted day:2014-04-10
Information query
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