Invention Grant
US09074210B2 Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF
有权
通过抑制BDNF的天然反义转录物治疗脑源性神经营养因子（BDNF）相关疾病
- Patent Title: Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF
- Patent Title (中): 通过抑制BDNF的天然反义转录物治疗脑源性神经营养因子（BDNF）相关疾病
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Application No.: US13201254Application Date: 2010-02-12
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Publication No.: US09074210B2Publication Date: 2015-07-07
- Inventor: Joseph Collard , Olga Khorkova Sherman , Carlos Coito
- Applicant: Joseph Collard , Olga Khorkova Sherman , Carlos Coito
- Applicant Address: US FL Miami
- Assignee: CuRNA, Inc.
- Current Assignee: CuRNA, Inc.
- Current Assignee Address: US FL Miami
- Agency: CuRNA, Inc.
- Agent Monte R. Browder
- International Application: PCT/US2010/024075 WO 20100212
- International Announcement: WO2010/093904 WO 20100819
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N5/00 ; C12N15/113 ; A61K31/7088 ; A61K45/06 ; A61K48/00
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Brain derived neurotrophic factor (BDNF), in particular, by targeting natural antisense polynucleotides of Brain derived neurotrophic factor (BDNF). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of BDNF.
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