Invention Grant
- Patent Title: Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
- Patent Title (中): 从相应的酮制备对映体富集的氘代仲醇而不减少氘掺入的方法
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Application No.: US13819985Application Date: 2011-09-01
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Publication No.: US09074233B2Publication Date: 2015-07-07
- Inventor: Ramanaiah C. Kanamarlapudi , Steven A. Weissman , Emerich Eisenreich , Xuejun Liu
- Applicant: Ramanaiah C. Kanamarlapudi , Steven A. Weissman , Emerich Eisenreich , Xuejun Liu
- Applicant Address: US MA Lexington
- Assignee: Concert Pharmaceuticals, Inc.
- Current Assignee: Concert Pharmaceuticals, Inc.
- Current Assignee Address: US MA Lexington
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Emily Dertz
- International Application: PCT/US2011/050139 WO 20110901
- International Announcement: WO2012/031073 WO 20120308
- Main IPC: C12P17/18
- IPC: C12P17/18 ; C07B35/02 ; C07D473/10 ; C07B59/00
Abstract:
The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation.
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