Invention Grant
US09074238B2 Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease
有权
在阿尔茨海默病患者中增强尼泊尔汀活性和降解淀粉样蛋白β肽和寡聚体的方法
- Patent Title: Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease
- Patent Title (中): 在阿尔茨海默病患者中增强尼泊尔汀活性和降解淀粉样蛋白β肽和寡聚体的方法
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Application No.: US13467036Application Date: 2012-05-08
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Publication No.: US09074238B2Publication Date: 2015-07-07
- Inventor: Chaur-Jong Hu , Po-Ting Chen , Rita P.-Y. Chen , Steven Sheng-Shih Wang
- Applicant: Chaur-Jong Hu , Po-Ting Chen , Rita P.-Y. Chen , Steven Sheng-Shih Wang
- Applicant Address: TW Taipei
- Assignee: ACADEMIA SINICA
- Current Assignee: ACADEMIA SINICA
- Current Assignee Address: TW Taipei
- Agency: Intellectual Property Connections, Inc.
- Agent Hsiu-Ming Saunders
- Main IPC: A61K31/235
- IPC: A61K31/235 ; C12Q1/37 ; C07C49/248 ; C07C59/84 ; C07C59/90 ; C07K7/06 ; C07C49/255 ; C07C49/235 ; C07C225/22 ; C12Q1/02 ; G01N33/50 ; C07C49/223 ; C07K14/47
Abstract:
A method of enhancing neprilysin activity and/or degrading amyloid-β peptides and/or oligomers in a subject with Alzheimer's disease is disclosed. The method comprises administering to the subject a compound selected from the group consisting of in a therapeutically effective amount to enhance the neprilysin activity and/or degrade the amyloid-β peptides and oligomers in the subject. Methods of improving symptoms and/or retarding progression of Alzheimer's disease and prophylactic treatment and/or treatment of Alzheimer's disease are also disclosed.
Public/Granted literature
- US20130102498A1 COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY Public/Granted day:2013-04-25
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