A vehicle door structure in which it is possible to prevent a slide opening and closing door panel from being uncoupled from a swing opening and closing door panel when the swing opening and closing door panel is opened, is provided. A vehicle door structure 10 includes a lock mechanism 22 that locks a slide door panel 14 to a swing door panel 16 when the swing door panel 16 is opened. The lock mechanism 22 is composed of a locking part 50 which is provided so as to be movable backward and forward along a direction in which the slide door panel 14 and the swing door panel 16 overlap each other according to opening and closing of the swing door panel 16, and a protrusion 60 which is provided on the slide door panel 14, and is locked by the locking part 50 when the swing door panel 16 is opened. The locking part 50 moves forward to the slide door panel 14 side, to lock the protrusion 60 when the swing door panel 16 is opened.