Invention Grant
- Patent Title: Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis
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Application No.: US13911242Application Date: 2013-06-06
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Publication No.: US09075045B2Publication Date: 2015-07-07
- Inventor: David Alan Zacharias , Sonia Lobo Planey
- Applicant: THE COMMONWEALTH MEDICAL COLLEGE , UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
- Applicant Address: US PA Scranton US FL Gainesville
- Assignee: The Commonwealth Medical College,University of Florida Research Foundation, Inc.
- Current Assignee: The Commonwealth Medical College,University of Florida Research Foundation, Inc.
- Current Assignee Address: US PA Scranton US FL Gainesville
- Agency: Caesar Rivise, PC
- Main IPC: C07K14/705
- IPC: C07K14/705 ; G01N33/50 ; C07K9/00 ; C12Q1/68 ; G01N33/68
Abstract:
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
Public/Granted literature
- US20140193835A1 CELL-BASED DETECTION OF APF THROUGH ITS INTERACTION WITH CKAP4 FOR DIAGNOSIS OF INTERSTITIAL CYSTITIS Public/Granted day:2014-07-10
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