Invention Grant
US09075050B2 Methods for assessing atherogenesis by determining oxidized phospholipid to apolipoprotein B ratios
有权
通过测定氧化磷脂对载脂蛋白B的比例来评估动脉粥样化形成的方法
- Patent Title: Methods for assessing atherogenesis by determining oxidized phospholipid to apolipoprotein B ratios
- Patent Title (中): 通过测定氧化磷脂对载脂蛋白B的比例来评估动脉粥样化形成的方法
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Application No.: US14048809Application Date: 2013-10-08
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Publication No.: US09075050B2Publication Date: 2015-07-07
- Inventor: Sotirios Tsimikas , Joseph L. Witztum
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Gavrilovich, Dodd & Lindsey LLP
- Agent Joseph R. Baker, Jr.
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/92
Abstract:
The present invention provides methods to analyze oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary syndromes (ACS) such as unstable angina and acute myocardial infarction or suspected of being at risk for ACS. Such methods are useful for diagnostic purposes and for monitoring the effects of dietary interventions or with drugs such as statins. More particularly, the disclosure provides methods for determining OxPL/apoB ratios as indices of atherosclerosis regression and plaque stability.
Public/Granted literature
- US20140309124A1 METHODS FOR ASSESSING ATHEROGENESIS BY DETERMINING OXIDIZED PHOSPHOLIPID TO APOLIPOPROTEIN B RATIOS Public/Granted day:2014-10-16
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