Intelligent technique is an effective method to perform the network resource management. A three layer cascade adaptive neural fuzzy inference system (ANFIS) based intelligent controller is proposed for the mobile wireless network to optimize the maximum average throughput, minimum transmit power and interference for multimedia call services. The proposed intelligent controller is designed with a three layer cascade architecture, which mainly contains an ANFIS rate controller (ARC) in the first layer, an ANFIS power controller (APC) in the second layer and an ANFIS interference controller (AIC) in the third layer. The design aim of the proposed three layer cascade ANFIS cognitive engine is maximizing the average throughput of the mobile wireless network, while minimizing the transmit power and interference power.