The present invention relates to methods and arrangements in a wireless communication system, and in particular to uplink outer loop power control. A Node B identifies if a UE from which the Node B receives data is in a predetermined set of power challenged situations. The Node B transmits to the RNC an indication to hold the SIR target of the UE if the UE has been identified to be in a power challenged situation. As a consequence, the uplink outer loop power control (OLPC) procedure in the RNC will not change the SIR target of the UE. This implies that the output power level of the UE remains unchanged as long as the UE remains in the power challenged situation. Thus, user and network performance are improved in the wireless communication system.