This invention discloses a system, method and computer-readable medium for actively cancelling interference signals. The system mentioned above communicates with at least one first transceiver. The abovementioned system includes at least one second transceiver, and a relay base station receiving a feedback signal from the at least one second transceiver and an environmental signal to execute a signal correlation function to get a result and determining to generate an anti-interference signal depending on the result. Herein, the relay base station cancels interference signals around the at least one first transceiver by sending the anti-interference signal to the at least one first transceiver via at least one third transceiver having an optimal communication channel to the at least one first transceiver.