Invention Grant
US09084806B2 Hypoxia-responsive nanoparticle for therapy and imaging of hypoxia-involving diseases
有权
低氧反应性纳米颗粒用于治疗和低氧相关疾病的成像
- Patent Title: Hypoxia-responsive nanoparticle for therapy and imaging of hypoxia-involving diseases
- Patent Title (中): 低氧反应性纳米颗粒用于治疗和低氧相关疾病的成像
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Application No.: US14078075Application Date: 2013-11-12
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Publication No.: US09084806B2Publication Date: 2015-07-21
- Inventor: Jae Hyung Park
- Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
- Applicant Address: KR Suwon-si
- Assignee: Research & Business Foundation Sungkyunkwan University
- Current Assignee: Research & Business Foundation Sungkyunkwan University
- Current Assignee Address: KR Suwon-si
- Agency: NSIP Law
- Priority: KR10-2012-0127483 20121112
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K31/704 ; A61K47/48 ; A61K9/51
Abstract:
The present invention relates to an amphiphilic polymer whose property and structure can change under hypoxic conditions, and to nanoparticles formed by self-assembly of the amphiphilic polymer. The hypoxia-responsive nanoparticles according to the present invention release a drug selectively under hypoxic conditions. Thus, the nanoparticles can be used for the selective diagnosis and treatment for diseases that are accompanied by hypoxia. Particularly, the nanoparticles can release a drug only to a targeted tumor in cancer therapy, and thus have minimized side effects and maximized therapeutic effects.
Public/Granted literature
- US20140141084A1 HYPOXIA-RESPONSIVE NANOPARTICLE FOR THERAPY AND IMAGING OF HYPOXIA-INVOLVING DISEASES Public/Granted day:2014-05-22
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