A seal assembly for sealing an interface between a structure having a side wall having an opening therein and a slide-out compartment that may be extended and retracted through the opening includes a first channel attached to the side wall and a complementary second channel attached to the compartment. The first channel includes a pair of wiper seals. The second channel is movable with respect to the first channel such that a flange of the second channel may be received within an interior of the first channel in engagement with the pair of wiper seals.