Invention Grant
- Patent Title: Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
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Application No.: US14268753Application Date: 2014-05-02
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Publication No.: US09085531B2Publication Date: 2015-07-21
- Inventor: Bruce F. Molino , Shuang Liu , Peter R. Guzzo , James P. Beck
- Applicant: Albany Molecular Research, Inc. , Bristol-Meyers Squibb Company
- Applicant Address: US NY Albany US NJ Princeton
- Assignee: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- Current Assignee: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- Current Assignee Address: US NY Albany US NJ Princeton
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D217/02 ; A61K31/47 ; C07D217/00 ; A61K31/4709 ; A61K31/4741 ; A61K31/4743 ; A61K31/502 ; A61K31/517 ; A61K31/53 ; C07D217/04 ; C07D217/08 ; C07D217/12 ; C07D217/14 ; C07D217/16 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D405/04 ; C07D405/12 ; C07D405/14 ; C07D409/04 ; C07D409/12 ; C07D409/14 ; C07D413/04 ; C07D413/12 ; C07D413/14 ; C07D417/04 ; C07D417/12 ; C07D417/14 ; C07D471/04 ; C07D487/04 ; C07D495/04 ; C07D217/20

Abstract:
The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.
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