Invention Grant
US09085554B2 Method of evaluating pharmaceutical preparation containing luliconazole and index substance
有权
评价含有luliconazole和指标物质的药物制剂的方法
- Patent Title: Method of evaluating pharmaceutical preparation containing luliconazole and index substance
- Patent Title (中): 评价含有luliconazole和指标物质的药物制剂的方法
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Application No.: US14592695Application Date: 2015-01-08
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Publication No.: US09085554B2Publication Date: 2015-07-21
- Inventor: Takaaki Masuda , Hiroshi Yamaguchi
- Applicant: POLA PHARMA INC. , NIHON NOHYAKU CO., LTD.
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: POLA PHARMA INC.,NIHON NOHYAKU CO., LTD.
- Current Assignee: POLA PHARMA INC.,NIHON NOHYAKU CO., LTD.
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: JP2013-256584 20131212
- Main IPC: C07D409/06
- IPC: C07D409/06 ; G01N30/02

Abstract:
Disclosed is a method of evaluating stability of a pharmaceutical preparation containing luliconazole. The method includes measuring an amount of production of an SE form of luliconazole represented by following formula (2), an amount of production of a Z form of luliconazole represented by following formula (3) and an amount of production of an amide form of luliconazole represented by following formula (1) after storage under a severe condition or an accelerated condition, and judging that the stability of the pharmaceutical preparation is high if each of the amount of production of the SE form, the amount of production of the Z form and the amount of production of the amide form is not more than 5% by weight with respect to a compounded amount of luliconazole.
Public/Granted literature
- US20150168357A1 METHOD OF EVALUATING PHARMACEUTICAL PREPARATION CONTAINING LULICONAZOLE AND INDEX SUBSTANCE Public/Granted day:2015-06-18
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