Invention Grant
US09085772B2 Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell
有权
抑制癌细胞中受体酪氨酸激酶介导的原始存活信号传导的方法
- Patent Title: Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell
- Patent Title (中): 抑制癌细胞中受体酪氨酸激酶介导的原始存活信号传导的方法
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Application No.: US13976186Application Date: 2011-12-26
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Publication No.: US09085772B2Publication Date: 2015-07-21
- Inventor: Takashi Takahashi , Tomoya Yamaguchi
- Applicant: Takashi Takahashi , Tomoya Yamaguchi
- Applicant Address: JP Aichi-ken
- Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- Current Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
- Current Assignee Address: JP Aichi-ken
- Agency: Sughrue Mion, PLLC
- Priority: JP2010-290373 20101227
- International Application: PCT/JP2011/080083 WO 20111226
- International Announcement: WO2012/090939 WO 20120705
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/113 ; A61K31/7088 ; C12Q1/48 ; G01N33/50 ; G01N33/574 ; G01N33/566 ; A61K38/22 ; A61K35/17 ; A61K35/745
Abstract:
In order to provide a screening method for a compound capable of suppressing a mechanism of ROR1 by targeting ROR1 and to provide a drug comprising as an active ingredient a compound capable of suppressing the mechanism, it has been found out that suppressing a function of ROR1 makes it possible to suppress receptor tyrosine kinase-mediated pro-survival signaling in a cancer cell. Further, it has been found out that suppressing a function of ROR1 also effectively suppresses growth of cancer cell lines having acquired resistance to inhibitors of receptor tyrosine kinases such as EGFR and MET.
Public/Granted literature
- US20130338214A1 METHOD FOR SUPPRESSING RECEPTOR TYROSINE KINASE-MEDIATED PRO-SURVIVAL SIGNALING IN CANCER CELL Public/Granted day:2013-12-19
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