Invention Grant
US09095414B2 Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
有权
非线性光学光动力疗法（NLO-PDT）的角膜
- Patent Title: Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
- Patent Title (中): 非线性光学光动力疗法（NLO-PDT）的角膜
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Application No.: US13919547Application Date: 2013-06-17
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Publication No.: US09095414B2Publication Date: 2015-08-04
- Inventor: James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyui Chai , Moritz Winkler
- Applicant: James V. Jester , Tibor Juhasz , Donald J. Brown , Dongyui Chai , Moritz Winkler
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61B18/20
- IPC: A61B18/20 ; A61F9/008 ; A61F9/01 ; A61N5/06
Abstract:
The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.
Public/Granted literature
- US20130338650A1 NONLINEAR OPTICAL PHOTODYNAMIC THERAPY (NLO-PDT) OF THE CORNEA Public/Granted day:2013-12-19
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