An artificial heart with a centrifugal pump is disclosed. In one embodiment, the artificial heart includes an impeller disposed in a housing. The impeller is configured to rotate to circulate blood through the housing. The impeller may include a set of blades on a first side of the impeller and a set of vanes on a second side opposite the first. The blades on the first side and the vanes on the second side allow blood circulation from both the first and the second sides of the impeller. The artificial heart may also or instead include a diffuser with adjustable vanes that enable variation in the output characteristics of the artificial heart pump. Various other artificial hearts, pumps, systems, and methods, including control systems and methods, are also disclosed.