Invention Grant
- Patent Title: Enteric coated granule and method for preparing the same
- Patent Title (中): 肠溶包衣颗粒及其制备方法
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Application No.: US11764084Application Date: 2007-06-15
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Publication No.: US09095513B2Publication Date: 2015-08-04
- Inventor: Mutsunori Tanji , Tadashi Matsui , Shuichiro Yuasa , Yuichi Nishiyama , Yuichi Ito , Ikuo Fukui
- Applicant: Mutsunori Tanji , Tadashi Matsui , Shuichiro Yuasa , Yuichi Nishiyama , Yuichi Ito , Ikuo Fukui
- Applicant Address: JP Tokyo
- Assignee: Shin-Etsu Chemical Co., Ltd.
- Current Assignee: Shin-Etsu Chemical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Alston & Bird LLP
- Priority: JP2006-167814 20060616
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K9/50

Abstract:
The present invention is an enteric coated granule having controlled dissolution in water even at a small coating amount; and a preparation method thereof. More specifically, provided are an enteric coated granule comprising a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule, a first enteric layer covering the raw granule or the granule, and a second enteric layer formed over the first enteric layer, wherein the first and the second enteric layers comprise a first and a second hydroxypropylmethyl cellulose acetate succinates (HPMCASs) different in solubility pH, respectively, and the solubility pH value of the second HPMCAS of the second enteric layer is lower than that of the first enteric layer; and a preparation method comprising steps of covering a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule with an enteric coating agent comprising a first HPMCAS to form a first enteric layer; and forming, over the first enteric layer, a second coating layer by using a second enteric coating agent comprising a second HPMCAS having a lower solubility pH value than that of the first HPMCAS.
Public/Granted literature
- US20070292509A1 ENTERIC COATED GRANULE AND METHOD FOR PREPARING THE SAME Public/Granted day:2007-12-20
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