Invention Grant
- Patent Title: Methods for affecting homology-directed DNA double stranded break repair
- Patent Title (中): 影响同源性DNA双链断裂修复的方法
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Application No.: US14028702Application Date: 2013-09-17
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Publication No.: US09095561B2Publication Date: 2015-08-04
- Inventor: Douglas Lee Pittman , Brian David Yard
- Applicant: University of South Carolina
- Applicant Address: US SC Columbia
- Assignee: University of South Carolina
- Current Assignee: University of South Carolina
- Current Assignee Address: US SC Columbia
- Agency: Dority & Manning, P.A.
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; A61K33/24 ; A61K31/7088 ; A61K38/53 ; C12N9/00 ; A61K31/407 ; A61K31/4745 ; A61K31/713 ; C12N15/113 ; C12Q1/68
Abstract:
Disclosed herein are methods and composition for alteration of the presence, activity, or concentration of RNF138. Disclosed methods can be utilized to affect DNA double strand break repair. Methods and compositions can be utilized to alter RNF138 so as to prevent interaction between RNF138 and RAD51D. Specifically, methods can prevent RNF138-directed ubiquitylation of RAD51D, which is necessary for DNA double strand break repair.
Public/Granted literature
- US20140010893A1 Methods for Affecting Homology-Directed DNA Double Stranded Break Repair Public/Granted day:2014-01-09
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