Invention Grant
US09095575B2 Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
有权
1-（取代磺酰基）-2-氨基咪唑啉的衍生物作为抗肿瘤剂和抗增殖剂
- Patent Title: Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
- Patent Title (中): 1-（取代磺酰基）-2-氨基咪唑啉的衍生物作为抗肿瘤剂和抗增殖剂
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Application No.: US14249226Application Date: 2014-04-09
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Publication No.: US09095575B2Publication Date: 2015-08-04
- Inventor: Stanislaw Wieslaw Pikul , Wieslaw Marek Cholody
- Applicant: OncoArendi Therapeutics Sp. z o.o.
- Agency: Seed IP Law Group PLLC
- Priority: PL403491 20130410
- Main IPC: A61K31/4168
- IPC: A61K31/4168 ; C07D403/12 ; C07D405/14 ; A61K31/4178 ; C07D401/14 ; A61K31/454 ; C07D409/14 ; C07D403/14 ; A61K31/506 ; A61K31/4439 ; A61K31/4709 ; A61K45/06 ; C07C247/06
Abstract:
The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general Formula (I) as well as some precursors of Formula (I), which are very potent inducers of G2/M cell cycle arrest. In treated tumor cells, compounds of Formula (I) give gene expression profile distinct from known antimitotic agents. The invention also provides methods for preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirably high levels of cell proliferation. The compounds of the invention are also expected to have utility as research tools.
Public/Granted literature
- US20140309240A1 DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS Public/Granted day:2014-10-16
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