Invention Grant
US09095613B2 Photosensitizer-metal nanoparticle charge complex and composition containing the complex for photodynamic therapy or diagnosis
有权
光敏剂 - 金属纳米粒子电荷复合物和含有光动力学治疗或诊断复合物的组合物
- Patent Title: Photosensitizer-metal nanoparticle charge complex and composition containing the complex for photodynamic therapy or diagnosis
- Patent Title (中): 光敏剂 - 金属纳米粒子电荷复合物和含有光动力学治疗或诊断复合物的组合物
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Application No.: US12673122Application Date: 2009-10-28
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Publication No.: US09095613B2Publication Date: 2015-08-04
- Inventor: Yong-Doo Choi , Bo-Seung Jang , Jin-Young Park , Jung-Im Lee , In-Hoo Kim
- Applicant: Yong-Doo Choi , Bo-Seung Jang , Jin-Young Park , Jung-Im Lee , In-Hoo Kim
- Applicant Address: KR Gyeonggi-Do
- Assignee: NATIONAL CANCER CENTER
- Current Assignee: NATIONAL CANCER CENTER
- Current Assignee Address: KR Gyeonggi-Do
- Agency: Foley & Lardner LLP
- Agent Michael Morency
- International Application: PCT/KR2009/006263 WO 20091028
- International Announcement: WO2011/049256 WO 20110428
- Main IPC: A61B10/00
- IPC: A61B10/00 ; A61B5/00 ; A61B8/00 ; A61K41/00 ; A61K33/24 ; A61K49/00

Abstract:
Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.
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