Invention Grant
US09096546B2 Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
有权
芳基和杂芳基取代的四氢苯并-1,4-二氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
- Patent Title: Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
- Patent Title (中): 芳基和杂芳基取代的四氢苯并-1,4-二氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取
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Application No.: US12598882Application Date: 2008-05-08
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Publication No.: US09096546B2Publication Date: 2015-08-04
- Inventor: Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson , Larry Yet
- Applicant: Peter R. Guzzo , Bruce F. Molino , Wenge Cui , Shuang Liu , Richard E. Olson , Larry Yet
- Applicant Address: US NY Albany US NJ Princeton
- Assignee: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- Current Assignee: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- Current Assignee Address: US NY Albany US NJ Princeton
- Agency: LeClairRyan, a Professional Corporation
- International Application: PCT/US2008/063039 WO 20080508
- International Announcement: WO2008/141081 WO 20081120
- Main IPC: A61K31/5513
- IPC: A61K31/5513 ; C07D243/14 ; C07D401/02 ; C07D403/02 ; C07D401/04 ; C07D403/04 ; C07D403/12 ; C07D405/14 ; C07D471/04
Abstract:
The aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepine derivative compounds of the present invention are represented by formulae 1(A-D) having the following structure: where the substituents X and R1-R8 are as defined herein.
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