Invention Grant
- Patent Title: Compounds useful as inhibitors of ATR kinase
- Patent Title (中): 可用作ATR激酶抑制剂的化合物
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Application No.: US13106178Application Date: 2011-05-12
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Publication No.: US09096584B2Publication Date: 2015-08-04
- Inventor: Jean-Damien Charrier , Steven John Durrant , Ronald Marcellus Alphonsus Knegtel , Philip Michael Reaper
- Applicant: Jean-Damien Charrier , Steven John Durrant , Ronald Marcellus Alphonsus Knegtel , Philip Michael Reaper
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agent Rory C. Stewart
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K31/4245 ; C07D213/82 ; C07D413/04
Abstract:
The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula III: wherein the variables are as defined herein.
Public/Granted literature
- US20120177748A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE Public/Granted day:2012-07-12
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